Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta

• Main Authors: Sara Calenda (Author), Daniela Catarzi (Author), Flavia Varano (Author), Erica Vigiani (Author), Rosaria Volpini (Author), Catia Lambertucci (Author), Andrea Spinaci (Author), Letizia Trevisan (Author), Ilenia Grieco (Author), Stephanie Federico (Author), Giampiero Spalluto (Author), Gianluca Novello (Author), Veronica Salmaso (Author), Stefano Moro (Author), Vittoria Colotta (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis. CK1δ overexpression, and the consequent hyperphosphorylation of specific proteins, can lead to sleep disorders, cancer, and neurodegenerative...