Doxorubicin/Nucleophosmin Binding Protein-Conjugated Nanoparticle Enhances Anti-leukemia Activity in Acute Lymphoblastic Leukemia Cells in vitro and in vivo

• Main Authors: Donghui Gan (Author), Yuwen Chen (Author), Zhengjun Wu (Author), Liping Luo (Author), Shimuye Kalayu Yirga (Author), Na Zhang (Author), Fu Ye (Author), Haijun Chen (Author), Jianda Hu (Author), Yingyu Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lymphoblastic leukemia (ALL) is an aggressive malignancy. Adults with ALL have more than 50% relapse rates. We have previously validated that overexpression of nucleophosmin (NPM) is involved in the multidrug resistance (MDR) development during ALL; and a synthetically engineered recombinant N...