Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer

• Main Authors: Gareth C. G. Davies (Author), Neesha Dedi (Author), Paul S. Jones (Author), Lara Kevorkian (Author), David McMillan (Author), Cristina Ottone (Author), Monika-Sarah E. D. Schulze (Author), Anthony Scott-Tucker (Author), Roohi Tewari (Author), Shauna West (Author), Michael Wright (Author), Tania F. Rowley (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTGremlin-1, a high-affinity antagonist of bone morphogenetic proteins (BMP)-2, −4, and −7, is implicated in tumor initiation and progression. Increased gremlin-1 expression, and therefore suppressed BMP signaling, correlates with poor prognosis in a range of cancer types. A lack of published...