Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations

• 主要な著者: Ai Goto (著者), Ryuichi Kambayashi (著者), Hiroko Izumi-Nakaseko (著者), Makoto Shinozaki (著者), Yoshinori Takei (著者), Atsushi Sugiyama (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2023-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

We simultaneously assessed electropharmacological effects of anti-atrial fibrillatory drug vernakalant and its potential risk toward torsade de pointes. Vernakalant hydrochloride in doses of 0.3 and 3 mg/kg/10 min was intravenously administered to isoflurane-anesthetized beagle dogs without (n = 5)...