Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations

Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations

We simultaneously assessed electropharmacological effects of anti-atrial fibrillatory drug vernakalant and its potential risk toward torsade de pointes. Vernakalant hydrochloride in doses of 0.3 and 3 mg/kg/10 min was intravenously administered to isoflurane-anesthetized beagle dogs without (n = 5)...

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Main Authors: Ai Goto (Author), Ryuichi Kambayashi (Author), Hiroko Izumi-Nakaseko (Author), Makoto Shinozaki (Author), Yoshinori Takei (Author), Atsushi Sugiyama (Author)
Format: Book
Published: Elsevier, 2023-08-01T00:00:00Z.
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