Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex

• Main Authors: Maria João Correia (Author), António B. Pimpão (Author), Filipa Lopes-Coelho (Author), Catarina O. Sequeira (Author), Nuno R. Coelho (Author), Clara Gonçalves-Dias (Author), Robert Barouki (Author), Xavier Coumoul (Author), Jacinta Serpa (Author), Judit Morello (Author), Emília C. Monteiro (Author), Sofia A. Pereira (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). Using a rat model of CIH-HTN, we investigated the imp...