Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice

• Main Authors: Xiao-Wen Chen (Author), Xiao-Yan Du (Author), Yu-Xian Wang (Author), Jian-Cheng Wang (Author), Wen-Ting Liu (Author), Wen-Jing Chen (Author), Hong-Yu Li (Author), Fen-Fen Peng (Author), Zhao-Zhong Xu (Author), Hong-Xin Niu (Author), Hai-Bo Long (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The receptor activator of NF-κB ligand (RANKL) and its receptor RANK are overexpressed in focal segmental glomerular sclerosis (FSGS), IgA nephropathy (IgAN), and membranous nephropathy (MN). However, the expression and the potential roles of RANKL and RANK in diabetic nephropathy (DN) remain unclea...