Tissue pharmacokinetics of DHP107, a novel lipid‐based oral formulation of paclitaxel, in mice and patients by positron emission tomography

• Main Authors: Byung Seok Moon (Author), Hyun Soo Park (Author), Jung Sunwoo (Author), In‐Hyun Lee (Author), Anhye Kim (Author), Seol Ju Moon (Author), Heechan Lee (Author), Min Hee Son (Author), Su Bin Kim (Author), Sun Mi Park (Author), Sang‐Keun Woo (Author), Jun‐Hee Jang (Author), Bom Sahn Kim (Author), Jee Hyun Kim (Author), Sang Eun Kim (Author), Howard Lee (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract DHP107 is a newly developed lipid‐based oral formulation of paclitaxel. We evaluated the in vivo tissue pharmacokinetics (PKs) of DHP107 in mice and patients using positron emission tomography (PET). Radioisotope‐labeled [3H]DHP107 and [18F]DHP107 for oral administration were formulated in...