Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway

• Main Authors: Arnau Biosca (Author), Miriam Ramírez (Author), Alex Gomez-Gomez (Author), Aritz Lafuente (Author), Valentín Iglesias (Author), Oscar J. Pozo (Author), Santiago Imperial (Author), Xavier Fernàndez-Busquets (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. The apicoplast organelle is a preferred target of...