Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor

Background: Aberrant activation of RAS-RAF-MEK-ERK signaling pathway has been implicated in more than one-third of all malignancies. MEK inhibitors are promising therapeutic approaches to target this signaling pathway. Though four MEK inhibitors have been approved by FDA, these compounds possess eit...

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Bibliographic Details
Main Authors: Yahong Liu (Author), Ying Cheng (Author), Gongchao Huang (Author), Xiangying Xia (Author), Xingkai Wang (Author), Hongqi Tian (Author)
Format: Book
Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
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