Preclinical characterization of tunlametinib, a novel, potent, and selective MEK inhibitor
Background: Aberrant activation of RAS-RAF-MEK-ERK signaling pathway has been implicated in more than one-third of all malignancies. MEK inhibitors are promising therapeutic approaches to target this signaling pathway. Though four MEK inhibitors have been approved by FDA, these compounds possess eit...
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Main Authors: | Yahong Liu (Author), Ying Cheng (Author), Gongchao Huang (Author), Xiangying Xia (Author), Xingkai Wang (Author), Hongqi Tian (Author) |
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Format: | Book |
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Frontiers Media S.A.,
2023-09-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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