Dexmedetomidine ameliorates acute kidney injury by regulating mitochondrial dynamics via the α2-AR/SIRT1/PGC-1α pathway activation in rats

• Main Authors: Shuai Zhang (Author), Xiujing Feng (Author), Guiyan Yang (Author), Haoyang Tan (Author), Xin Cheng (Author), Qichao Tang (Author), Haotian Yang (Author), Yuan Zhao (Author), Xuanpan Ding (Author), Siyao Li (Author), Xinyi Dou (Author), Junfeng Li (Author), Huijie Kang (Author), Xingxing Li (Author), Yaxin Ji (Author), Qingdian Hou (Author), Qiuyue An (Author), Hao Fang (Author), Honggang Fan (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sepsis-associated acute kidney injury (AKI) is a serious complication of systemic infection with high morbidity and mortality in patients. However, no effective drugs are available for AKI treatment. Dexmedetomidine (DEX) is an alpha 2 adrenal receptor agonist with antioxidant an...