Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens.

• Main Authors: Li Liang (Author), Diana Leng (Author), Chad Burk (Author), Rie Nakajima-Sasaki (Author), Matthew A Kayala (Author), Vidya L Atluri (Author), Jozelyn Pablo (Author), Berkay Unal (Author), Thomas A Ficht (Author), Eduardo Gotuzzo (Author), Mayuko Saito (Author), W John W Morrow (Author), Xiaowu Liang (Author), Pierre Baldi (Author), Robert H Gilman (Author), Joseph M Vinetz (Author), Renée M Tsolis (Author), Philip L Felgner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brucellosis is a widespread zoonotic disease that is also a potential agent of bioterrorism. Current serological assays to diagnose human brucellosis in clinical settings are based on detection of agglutinating anti-LPS antibodies. To better understand the universe of antibody responses that develop...