RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. Th...

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Main Authors: Kerstin W. Sinkevicius (Author), Thomas R. Morrison (Author), Praveen Kulkarni (Author), Martha K. Caffrey Cagliostro (Author), Sade Iriah (Author), Samantha Malmberg (Author), Julia Sabrick (Author), Jennifer A. Honeycutt (Author), Kim L. Askew (Author), Malav Trivedi (Author), Craig F. Ferris (Author)
Format: Book
Published: The Company of Biologists, 2018-06-01T00:00:00Z.
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3rd Floor Main Library

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