RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

• Автори: Kerstin W. Sinkevicius (Автор), Thomas R. Morrison (Автор), Praveen Kulkarni (Автор), Martha K. Caffrey Cagliostro (Автор), Sade Iriah (Автор), Samantha Malmberg (Автор), Julia Sabrick (Автор), Jennifer A. Honeycutt (Автор), Kim L. Askew (Автор), Malav Trivedi (Автор), Craig F. Ferris (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2018-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. Th...