Influence of protein fold stability on immunogenicity and its implications for vaccine design

• Main Authors: Sandra Scheiblhofer (Author), Josef Laimer (Author), Yoan Machado (Author), Richard Weiss (Author), Josef Thalhamer (Author)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2017-05-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Introduction: In modern vaccinology and immunotherapy, recombinant proteins more and more replace whole organisms to induce protective or curative immune responses. Structural stability of proteins is of crucial importance for efficient presentation of antigenic peptides on MHC, which plays a decisi...