Emergence of a globally dominant IncHI1 plasmid type associated with multiple drug resistant typhoid.

• Main Authors: Kathryn E Holt (Author), Minh Duy Phan (Author), Stephen Baker (Author), Pham Thanh Duy (Author), Tran Vu Thieu Nga (Author), Satheesh Nair (Author), A Keith Turner (Author), Ciara Walsh (Author), Séamus Fanning (Author), Sinéad Farrell-Ward (Author), Shanta Dutta (Author), Sam Kariuki (Author), François-Xavier Weill (Author), Julian Parkhill (Author), Gordon Dougan (Author), John Wain (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a serious global health concern. Since their emergence in the mid-1970s multi-drug resistant (MDR) S. Typhi now dominate drug sensitive equivalents in many regions. MDR in S. Typhi is almost exclusively conferred by self-...