PLGA-PEG Nanoparticles Loaded with Cdc42 Inhibitor for Colorectal Cancer Targeted Therapy

• Main Authors: Sanazar Kadyr (Author), Altyn Zhuraliyeva (Author), Aislu Yermekova (Author), Aigerim Makhambetova (Author), Daulet B. Kaldybekov (Author), Ellina A. Mun (Author), Denis Bulanin (Author), Sholpan N. Askarova (Author), Bauyrzhan A. Umbayev (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background/Objectives:</b> An inhibitor of small Rho GTPase Cdc42, CASIN, has been shown to reduce cancer cell proliferation, migration, and invasion, yet it has several limitations, including rapid drug elimination and low bioavailability, which prevents its systemic administration....