PAMAM dendrimers of generation 4.5 loaded with curcumin interfere with α-synuclein aggregation

• Main Authors: Daniela E. Igartúa (Author), Florencia González-Lizárraga (Author), Carolina S. Martinez (Author), Silvia del V. Alonso (Author), César L. Ávila (Author), Rosana Chehín (Author), Nadia S. Chiaramoni (Author), M. Jimena Prieto (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Curcumin (CUR) is a bioactive compound that has been proposed for the treatment of various neurodegenerative diseases. However, its use is limited due to its low solubility in aqueous media and chemical instability under physiological conditions. Herein, we propose a strategy to overcome these limit...