Doxycycline Inhibits IL-17-Stimulated MMP-9 Expression by Downregulating ERK1/2 Activation: Implications in Myogenic Differentiation

• Main Authors: Hristina Obradović (Author), Jelena Krstić (Author), Tamara Kukolj (Author), Drenka Trivanović (Author), Ivana Okić Đorđević (Author), Slavko Mojsilović (Author), Aleksandra Jauković (Author), Gordana Jovčić (Author), Diana Bugarski (Author), Juan Francisco Santibañez (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin 17 (IL-17) is a cytokine with pleiotropic effects associated with several inflammatory diseases. Although elevated levels of IL-17 have been described in inflammatory myopathies, its role in muscle remodeling and regeneration is still unknown. Excessive extracellular matrix degradation i...