Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [¹⁷⁷Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model

• Main Authors: Judith Anna Delage (Author), Alain Faivre-Chauvet (Author), Jacques Barbet (Author), Julie Katrin Fierle (Author), Niklaus Schaefer (Author), George Coukos (Author), David Viertl (Author), Steven Mark Dunn (Author), Silvano Gnesin (Author), John O. Prior (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

1C1m-Fc, an anti-tumor endothelial marker 1 (TEM-1) scFv-Fc fusion protein antibody, was previously successfully radiolabeled with ¹⁷⁷Lu. TEM-1 specific tumor uptake was observed together with a non-saturation dependent liver uptake that could be related to the number of dodec...