Formulation development of a stable influenza recombinant neuraminidase vaccine candidate

• Main Authors: Bing Li (Author), Irina V. Ustyugova (Author), Lisa Szymkowicz (Author), Shaolong Zhu (Author), Marin Ming (Author), Karen Y. Y. Fung (Author), Guadalupe Cortés (Author), D. Andrew James (Author), Michael Hrynyk (Author), Nausheen Rahman (Author), Roger H. Brookes (Author), Salvador F. Ausar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTCurrent influenza vaccines could be augmented by including recombinant neuraminidase (rNA) protein antigen to broaden protective immunity and improve efficacy. Toward this goal, we investigated formulation conditions to optimize rNA physicochemical stability. When rNA in sodium phosphate sal...