A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

• Main Authors: Georgina Askeland (Author), Marie Rodinova (Author), Hana Štufková (Author), Zaneta Dosoudilova (Author), Monika Baxa (Author), Petra Smatlikova (Author), Bozena Bohuslavova (Author), Jiri Klempir (Author), The Duong Nguyen (Author), Anna Kuśnierczyk (Author), Magnar Bjørås (Author), Arne Klungland (Author), Hana Hansikova (Author), Zdenka Ellederova (Author), Lars Eide (Author)
• Format: Book
• Published: The Company of Biologists, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans and exhibits slow disease progression, and is therefore more powerful than...