Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency‐Guided First‐in‐Human Studies

Many targeted therapies are administered at or near the maximum tolerated dose (MTD). With the advent of precision medicine, a larger therapeutic window is expected. Therefore, dose optimization will require a new approach to early clinical trial design. We analyzed publicly available data for 21 th...

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Main Authors: Matthew J. Goldstein (Author), Malte Peters (Author), Barbara L. Weber (Author), Charles B. Davis (Author)
Format: Book
Published: Wiley, 2021-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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