Key-Protease Inhibition Regimens Promote Tumor Targeting of Neurotensin Radioligands

• Main Authors: Panagiotis Kanellopoulos (Author), Aikaterini Kaloudi (Author), Marion de Jong (Author), Eric P. Krenning (Author), Berthold A. Nock (Author), Theodosia Maina (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurotensin subtype 1 receptors (NTS1R) represent attractive molecular targets for directing radiolabeled neurotensin (NT) analogs to tumor lesions for diagnostic and therapeutic purposes. This approach has been largely undermined by the rapid in vivo degradation of linear NT-based radioligands. Her...