Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects

• Principais autores: Zhixian Zhou (Autor), Huan Yin (Autor), Suye Suye (Autor), Zhen Ren (Autor), Lei Yan (Autor), Liye Shi (Autor), Chun Fu (Autor)
• Formato: Livro
• Publicado em: BMC, 2023-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Fanconi anemia (FA) gene mutations are critical components in the genetic etiology of premature ovarian insufficiency (POI). Fance −/− mice detected meiotic arrest of primordial germ cells (PGCs) as early as embryonic day (E) 13.5 and exhibited decreased ovarian reserve after birth. However...