Cancer and deregulation of stem cells pathways

• Main Authors: Filipe Correia Martins (Author), Maria Filomena Botelho (Author), António Manuel Cabrita (Author), Maria Isabel Torgal (Author), Carlos Freire de Oliveira (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stem cells may have an important etiological role in cancer. Their classic regulatory pathways are deregulated in tumors, strengthening the stem cell theory of cancer. In this manuscript, we review Wnt, Notch and Hedhehog pathways, describing which of their factors may be responsible for the neoplas...