The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

• Main Authors: Adam J. Rauckhorst (Author), Lawrence R. Gray (Author), Ryan D. Sheldon (Author), Xiaorong Fu (Author), Alvin D. Pewa (Author), Charlotte R. Feddersen (Author), Adam J. Dupuy (Author), Katherine N. Gibson-Corley (Author), James E. Cox (Author), Shawn C. Burgess (Author), Eric B. Taylor (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial matrix, thereby gating pyruvate-driven gluconeogen...