Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2)

• Main Authors: Yu-chi Shen (Author), Caroline Arellano-Garcia (Author), Rosa E. Menjivar (Author), Ethan M. Jewett (Author), Wolfgang Dohle (Author), Sofiia Karchugina (Author), Jonathan Chernoff (Author), Barry V. L. Potter (Author), Kate F. Barald (Author)
• Format: Book
• Published: BMC, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Neurofibromatosis 1 and 2, although involving two different tumour suppressor genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes that disproportionately affect cells of neural crest origin. New therapeutic approaches for both NF1 and NF2 are...