Histamine can be Formed and Degraded in the Human and Mouse Heart

• Main Authors: Joachim Neumann (Author), Juliane M. Grobe (Author), Jacqueline Weisgut (Author), Hubert G. Schwelberger (Author), Wieslawa Agnieszka Fogel (Author), Margaréta Marušáková (Author), Hartmut Wache (Author), Heike Bähre (Author), Igor B. Buchwalow (Author), Stefan Dhein (Author), Britt Hofmann (Author), Uwe Kirchhefer (Author), Ulrich Gergs (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in humans via H2-histamine receptors. In transgenic mice...