Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers

• Main Authors: Keisuke Motoki (Author), Takako Igarashi (Author), Koichi Omura (Author), Hiroshi Nakatani (Author), Takashi Iwanaga (Author), Ikumi Tamai (Author), Tetsuo Ohashi (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This study aimed to investigate the pharmacokinetic and pharmacodynamic (PK/PD) profiles of dotinurad, a novel uricosuric agent, and to construct a PK/PD model to predict serum urate (SUA) levels after dotinurad administration in healthy men. PK/PD model was constructed using single‐dose st...