Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD Resiquimod (R848), a tumor-targeting antibody spe...

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Main Authors: Lydia Bisbal Lopez (Author), Domenico Ravazza (Author), Matilde Bocci (Author), Aureliano Zana (Author), Lucrezia Principi (Author), Sheila Dakhel Plaza (Author), Andrea Galbiati (Author), Ettore Gilardoni (Author), Jörg Scheuermann (Author), Dario Neri (Author), Luca Pignataro (Author), Cesare Gennari (Author), Samuele Cazzamalli (Author), Alberto Dal Corso (Author)
Format: Book
Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
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