Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids

• Main Authors: Laxman Subedi (Author), Prashant Pandey (Author), Bikram Khadka (Author), Jung-Hyun Shim (Author), Seung-Sik Cho (Author), Seho Kweon (Author), Youngro Byun (Author), Ki-Taek Kim (Author), Jin Woo Park (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atorvastatin (ATV) has attracted considerable attention as a potential therapeutic agent for cancer because it inhibits cancer cell proliferation by suppressing the mevalonate pathway. However, because of its low oral absorption, high doses of ATV are required for chemotherapeutic applications. In t...