Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor

• Main Authors: Seiji Ueno (Author), Toru Kimura (Author), Takashi Yamaga (Author), Akihiko Kawada (Author), Toshiaki Ochiai (Author), Hitoshi Endou (Author), Hiroyuki Sakurai (Author)
• Format: Book
• Published: Elsevier, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: In many cancer cells, L-type amino acid transporter 1 (LAT1) transports neutral amino acids with bulky side chain, which activate mammalian target of rapamycin (mTOR) to cause cell proliferation. An anti-diabetic drug, metformin, has been shown to activate AMP-activated protein kinase (A...