Guanidines: Synthesis of Novel Histamine H₃R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect

• Main Authors: Marek Staszewski (Author), Magdalena Iwan (Author), Tobias Werner (Author), Marek Bajda (Author), Justyna Godyń (Author), Gniewomir Latacz (Author), Agnieszka Korga-Plewko (Author), Joanna Kubik (Author), Natalia Szałaj (Author), Holger Stark (Author), Barbara Malawska (Author), Anna Więckowska (Author), Krzysztof Walczyński (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study examines the properties of novel guanidines, designed and synthesized as histamine H₃R antagonists/inverse agonists with additional pharmacological targets. We evaluated their potential against two targets viz., inhibition of MDA-MB-231, and MCF-7 breast cancer cell...