Squalenoylated Nanoparticle Pro-Drugs of Adjuvant Antitumor 11α-Hydroxyecdysteroid 2,3-Acetonides Act as Cytoprotective Agents Against Doxorubicin and Paclitaxel

• Main Authors: Máté Vágvölgyi (Author), Péter Bélteky (Author), Dóra Bogdán (Author), Márta Nové (Author), Gabriella Spengler (Author), Ahmed D. Latif (Author), István Zupkó (Author), Tamás Gáti (Author), Gábor Tóth (Author), Zoltán Kónya (Author), Attila Hunyadi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several ecdysteroid acetonides act as adjuvant chemo-sensitizing agents against various cancer cell lines, and they can be formulated to self-assembling nanoparticle (NP) pro-drugs through a hydrolysable conjugation with squalene. In the bloodstream such squalenoylated nanoparticles dissolve into lo...