Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats

• Main Authors: Iwona Baranowska (Author), Olga Gawrys (Author), Agnieszka Walkowska (Author), Krzysztof H. Olszynski (Author), Luděk Červenka (Author), John R. Falck (Author), Adeniyi M. Adebesin (Author), John D. Imig (Author), Elżbieta Kompanowska-Jezierska (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial effects, such as vasodilatory activity and anti-infla...