Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis.

• Main Authors: Parna Bhattacharya (Author), Ranadhir Dey (Author), Pradeep K Dagur (Author), Amritanshu B Joshi (Author), Nevien Ismail (Author), Sreenivas Gannavaram (Author), Alain Debrabant (Author), Adovi D Akue (Author), Mark A KuKuruga (Author), Angamuthu Selvapandiyan (Author), John Philip McCoy (Author), Hira L Nakhasi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Visceral leishmaniasis (VL) caused by the protozoan parasite Leishmania donovani causes severe disease. Age appears to be critical in determining the clinical outcome of VL and at present there is no effective vaccine available against VL for any age group. Previously, we showed that gene...