N-acetylcysteine: pharmacokinetic parameters and the effect on the concentration of endogenous aminothiols

• Main Authors: A. A. Dutov (Author), D. A. Nikitin (Author), J. L. Lukianova (Author), N. A. Shemyakina (Author), A. V. Ermolina (Author), M. N. Mishchenko (Author)
• Format: Book
• Published: LLC "Publisher OKI", 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We studied the pharmacokinetic parameters of N-acetylcysteine at a single oral and intravenous administration of healthy volunteers. Elimination half-life (t1/2) within 2 hours and the maximum concentration in blood (Cmax) after 1 hour after administration was more than 10 times higher when intraven...