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Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline-Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors

A series of quinoline-uracil hybrids (<b>10a-l</b>) has been rationalized and synthesized. The inhibitory activity against hCA isoforms I, II, IX, and XII was explored. Compounds <b>10a-l</b> demonstrated powerful inhibitory activity against all tested hCA isoforms. Compound...

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Bibliographic Details
Main Authors:	Samar A. El-Kalyoubi (Author), Ehab S. Taher (Author), Tarek S. Ibrahim (Author), Mohammed Farrag El-Behairy (Author), Amany M. M. Al-Mahmoudy (Author)
Format:	Book
Published:	MDPI AG, 2022-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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