BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

• Главные авторы: Raymond Taylor (Автор), Pravin Kotian (Автор), Travis Warren (Автор), Rekha Panchal (Автор), Sina Bavari (Автор), Justin Julander (Автор), Sylvia Dobo (Автор), Angela Rose (Автор), Yahya El-Kattan (Автор), Brian Taubenheim (Автор), Yarlagadda Babu (Автор), William P. Sheridan (Автор)
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• Опубликовано: Elsevier, 2016-05-01T00:00:00Z.
• Предметы: article
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Summary: The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus. Cellular kinases phosphorylate BCX4430 to a triphosphate that mimics ATP; viral...