Development of QSAR models for in silico screening of antibody solubility

• Principais autores: Xuan Han (Autor), James Shih (Autor), Yuhao Lin (Autor), Qing Chai (Autor), Steven M. Cramer (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Although monoclonal antibodies (mAbs) have been shown to be extremely effective in treating a number of diseases, they often suffer from poor developability attributes, such as high viscosity and low solubility at elevated concentrations. Since experimental candidate screening is often materials and...