Precise Dosing of Pramipexole for Low-Dosed Filament Production by Hot Melt Extrusion Applying Various Feeding Methods

• Main Authors: Rebecca Chamberlain (Author), Hellen Windolf (Author), Simon Geissler (Author), Julian Quodbach (Author), Jörg Breitkreutz (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2022-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

The aim of this research was the production of low-dosed filaments via hot-melt extrusion (HME) with the model drug pramipexole for the treatment of Parkinson's disease. The active pharmaceutical ingredient (API) and one of the polymers polyvinyl alcohol (PVA) or basic butylated methacrylate co...