Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced p...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2017-11-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_ba15b3cc19cc43f58d2042f860bf4fc7 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Amani S. Awaad |e author |
| 700 | 1 | 0 | |a Ahmed M. Alafeefy |e author |
| 700 | 1 | 0 | |a Fatmah A.S. Alasmary |e author |
| 700 | 1 | 0 | |a Reham M. El-Meligy |e author |
| 700 | 1 | 0 | |a M.E. Zain |e author |
| 700 | 1 | 0 | |a Saleh I. Alqasoumi |e author |
| 245 | 0 | 0 | |a Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity |
| 260 | |b Elsevier, |c 2017-11-01T00:00:00Z. | ||
| 500 | |a 1319-0164 | ||
| 500 | |a 10.1016/j.jsps.2017.02.012 | ||
| 520 | |a A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging. | ||
| 546 | |a EN | ||
| 690 | |a Natural products hybrid | ||
| 690 | |a In-vitro | ||
| 690 | |a Anti-Helicobacter pylori | ||
| 690 | |a Amino acid | ||
| 690 | |a Sulfanilamide | ||
| 690 | |a Anti-ulcerogenic agent | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Saudi Pharmaceutical Journal, Vol 25, Iss 7, Pp 967-971 (2017) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1319016417300336 | |
| 787 | 0 | |n https://doaj.org/toc/1319-0164 | |
| 856 | 4 | 1 | |u https://doaj.org/article/ba15b3cc19cc43f58d2042f860bf4fc7 |z Connect to this object online. |