The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice

• Asıl Yazarlar: Hui Yu (Yazar), Angelika Chiang (Yazar), Marcelo Rubinstein (Yazar), Malcolm J. Low (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2024-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Objective: Proopiomelanocortin (POMC) neurons release potent anorexigenic neuropeptides, which suppress food intake and enhance energy expenditure via melanocortin receptors. Although the importance of central melanocortin in physiological regulation is well established, the underlying genetic mecha...