The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development

• Main Authors: Zhenxing Cheng (Author), Simon T. Abrams (Author), James Austin (Author), Julien Toh (Author), Susan Siyu Wang (Author), Zhi Wang (Author), Qian Yu (Author), Weiping Yu (Author), Cheng Hock Toh (Author), Guozheng Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pathological roles of bacterial DNA have been documented many decades ago. Bacterial DNAs are different from mammalian DNAs; the latter are heavily methylated. Mammalian cells have sensors such as TLR-9 to sense the DNAs with nonmethylated CpGs and distinguish them from host DNAs with methylated...