Inhibition of P-glycoprotein-Mediated Efflux of Digoxin and Its Metabolites by Macrolide Antibiotics

This study was conducted to determine the rate of P-glycoprotein (P-gp)-mediated efflux of digoxin analogues and metabolites and to assess the effects of macrolide antibiotics on this efflux. Bidirectional transport studies were conducted using our Caco-2 sub clone with high P-gp expression (CLEFF9)...

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Main Authors: Jeff Hughes (Author), Andrew Crowe (Author)
Format: Book
Published: Elsevier, 2010-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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