Impact of Peptide Structure on Colonic Stability and Tissue Permeability

• Main Authors: Farhan Taherali (Author), Nerisha Chouhan (Author), Fanjin Wang (Author), Sebastien Lavielle (Author), Maryana Baran (Author), Laura E. McCoubrey (Author), Abdul W. Basit (Author), Vipul Yadav (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Most marketed peptide drugs are administered parenterally due to their inherent gastrointestinal (GI) instability and poor permeability across the GI epithelium. Several molecular design techniques, such as cyclisation and D-amino acid (D-AA) substitution, have been proposed to improve oral peptide...