Characterization of the tumor microenvironment and identification of spatially predictive biomarkers associated with beneficial neoadjuvant chemoradiotherapy in locally advanced rectal cancer

• Main Authors: Shifen Zhang (Author), Na Li (Author), Feifei Wang (Author), Hailing Liu (Author), Yuhan Zhang (Author), Jinyuan Xiao (Author), Weihao Qiu (Author), Ceng Zhang (Author), Xinjuan Fan (Author), Mingxin Qiu (Author), Mingzhou Li (Author), Hongzhen Tang (Author), Shiheng Fan (Author), Jiaqian Wang (Author), Haitao Luo (Author), Xiangzhao Li (Author), Jie Lin (Author), Yan Huang (Author), Li Liang (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients with locally advanced rectal cancer (LARC). However, 20-40% of patients with LARC show little to no response to nCRT. Thus, comprehensively understanding the tumor microenvironment (TME), which might influence therap...