Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via <i>sox9</i> Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer

• Main Authors: Jagadeesh K. Venkatesan (Author), Weikun Meng (Author), Ana Rey-Rico (Author), Gertrud Schmitt (Author), Susanne Speicher-Mentges (Author), Céline Falentin-Daudré (Author), Amélie Leroux (Author), Henning Madry (Author), Véronique Migonney (Author), Magali Cucchiarini (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while protecting the cargos from detrimental immune responses, particularly when targeting chondrore...