Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

• Main Authors: Benedetta Fois (Author), Simona Distinto (Author), Rita Meleddu (Author), Serenella Deplano (Author), Elias Maccioni (Author), Costantino Floris (Author), Antonella Rosa (Author), Mariella Nieddu (Author), Pierluigi Caboni (Author), Claudia Sissi (Author), Andrea Angeli (Author), Claudiu T. Supuran (Author), Filippo Cottiglia (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical investigation of the extracts led to the isolation of te...